Posts Tagged ‘preventive medicine’

In a recent, widely anticipated decision that pertains to rights to some of what makes us us, a federal judge ruled in favor of patients, medical societies, and researchers, who were suing Myriad and the Utah University research foundation, owners of the patent on the two genes whose mutations had been associated with increased risk for breast and ovarian cancer, BRCA1 and BRCA2. Their ownership had allowed them to retain complete rights for these widely prescribed diagnostic tests, which have remained prohibitively expensive for many patients (currently at more than $3,000).

Interestingly, in taking the decision to invalidate such patents, the Department of Justice differs in its opinion from the US Patent and Trade Marks Office (USPTO). Meanwhile the status quo will be maintained. The Biotechnology Industry Organization (BIO), the organization that lobbies for the pharma and biotech companies, has been arguing since the beginning of the case that preventing patenting of human genes will literally impede life science innovation and had stated after the court’s decision that carrying this one out would: “undermine U.S. global leadership and investment in the life sciences”. A variety of people have spoken for and against the decision. The New York Times just wrote an article citing several of them.

The US government filled a “friend of the court” (or “Amicus curiae”) opinion entitled: ”BRIEF FOR THE UNITED STATES AS AMICUS CURIAE IN SUPPORT OF NEITHER PARTY” (you can read the pdf here ). As expected with these types of opinions (see Wiki)- and indicated by its title – the intent was not to support either of the parties. The last point listed in the government’s opinion constitutes a good summary: “Isolated Genomic DNA Is Not Patent-Eligible Merely Because It Is Useful Or Requires Investment To Identify.”

As someone who has dedicated her life to improving human health: I understand the need to recognize and reward discoveries, so that they may continue to advance the available diagnostic and therapeutic interventions. At the same time, in my opinion, a balance needs to found – or maybe a line needs to be drawn. Otherwise, these innovations will remain out of the reach of many patients who need them. The exact balance may not be easy to figure out or accept by consensus.

To what point should we own things we just happened to be the first to discover/figure out? Should various entities (researchers, universities, companies) own pieces of everybody’s proteins, DNA, or maybe their constituent atoms, electrons or the even more ephemeral particles and their interactions? These are all things that make us us. Or, going in the opposite direction, should each disease/syndrome or epidemic have owners that need to be paid before we could proceed with curing them? Am I right to assume that in such case, arrangements and payments would need to be exchanged between the owner of the gene and the person who had discovered the disease, with corresponding arrangements with those who had patented the smaller molecular or atomic pieces of the puzzle? How are we ever going to navigate such complex territorial and legal claims? Maybe Google could develop maps of the human body charting out the parcels to indicate ownership? I am on the opinion that we should only own things we create ourselves. In relation to this specific discussion, I think it is appropriate to own the rights to a new method to test or to control a gene, or a newly created molecule that could be used for diagnostic or therapeutic effect.

I know patients who were unable to take advantage of the BRCA test because of its prohibitive price and who knows how many more cases we might have failed to diagnose and treat because of these legally imposed economic barriers. Can you imagine that currently the actual cost of performing such a diagnostic test is only a few dollars? Would it be possible to compromise by assessing limits on the profit margin of diagnostic tests? I feel that we need to ensure that the initial intent – or what many say is – of our efforts to improve human health is not compromised.

What is your opinion? Should those sequencing one of the genes we all share – and its mutations – gain the exclusive rights to any diagnostic or therapeutic intervention that is related to that gene? Do you know who owns YOUR genes?

Read Full Post »

How about this reply to the ‘what’s in it for me?’ question on everyone’s mind when it comes to the US health care reform: “Freedom to innovate!”

The health care reform proposal spurred a lot of discussion that seems to have fueled more emotional energy than rational arguments, not surprisingly used for political, business, and who knows what other purposes! The new reform has been presented by many as a dangerous threat to personal freedom, strongly resonating with a nation which fiercely values its freedom above all. I want to submit the idea that a well-thought-out reform would more likely enhance our overall capacity to make personal choices beyond the existing health care plans and such would increase our degree of individual freedom. In addition, having competitive options is very much in line with the overall philosophy of the American society and could have a very beneficial effect on innovation in the US.

People strongly react to such ‘push buttons’ and they fear the unknown. I could share some different personal experiences as someone who had lived in other places where universal health care options are available. For instance, I grew up not missing a single day of school. Good genetics? Maybe! Being vaccinated against all the childhood diseases and attending schools that had dedicated physician, dentist, and assistants on site… more likely! My parents also never had to take time off (for me to see the doctor or to nurse me) and never had to worry about paying medical bills if I would have gotten sick. My experience as a parent in the US was different. Most of us agree that it is not working well and that repeating the same and expecting different  – usually better ! – results equals insanity.

A reform is creating the opportunity to innovate the health care in the US.We have a great opportunity to analyse the highs and lows of several different systems currently run in different parts of the world. A new system in the US does not need to be the same as the European or Canadian systems, but could incorporate their successful features. However, the administration, congress, media, providers and consumers – we all – should collaborate to innovate the health care in the US.

A health care reform will also enhance the overall opportunities to innovate in the US.  The availability of a good employer-independent option has the potential to release a lot of people from their current ‘job lock,’ or even from its de luxe version: the ‘golden cuffs.’ Due to worries of not being able to provide health care for their young children, energetic workers are often stuck in jobs they would rather change. More ‘seasoned’ skilled workers are often worried about not being able to cover for their own potential health issues likely to increase during their gray years. Under current circumstances all these people are understandably seeking work with companies that provide generous health plans that most smaller companies cannot offer. A good employer-independent option would level the playing field: many small(er) companies, including New Co, a major source of US innovation, would have an easier time attracting valuable employees. Having put the fear of not being able to cover health bills behind them, many workers could then seek better job fits for their skills and passions. Does anybody doubt that being motivated by our passions rather than our fears has positive effects upon the output? Innovating health care in the US has the potential to trigger a chain reaction with a tremendous beneficial impact on the overall US innovation capacity.

Coming back to ‘what’s in it for’ us personally, let’s add another thought. Many studies indicate that stress is bad for our health. Losing the serious stress over not being able to afford the medical bills for ourselves, family, and employees might itself increase our overall well-being!

Read Full Post »

You guessed it! Location, location, location

A new research study from my Alma Mater, McGill University in Montreal, demonstrates major DNA differences between genes in blood cells and tissue cells of the same individual. Specifically, the researchers found a DNA mutation (of the BAK gene involved in cell death) in the tissue cells harvested from patients, but not in their blood cells. This study and other recent ones challenge the major current assumption under which we have operated for years, i.e. that our DNA is the same in all the cells throughout the body, a specific master template faithfully reproduced in each of us. We are not talking cancer where local mutations are known to occur in tumors. What does this mean for you?

–       As a researcher, therapy and/or diagnostic developer, etc., it means that you will likely have to look in the right place in the body, analyzing “the right” (relevant) cells. This is exciting, as it opens up a lot of potential great discoveries, cures and diagnostics. It is also good news for those who had set up or already work with tissue banks (is anybody reading: much more work needed? are we going to run into the needle in the haystack issue?)

–       As a regulator, decision maker, media, etc. you will have to realize that there is much more to come, so you might want to give it a chance… Many have begun not only to openy question the wisdom of genetic testing to derive disease associations, but to actively block any initiative along these lines.

–        As a patient and consumer of health innovation, you might have to be willing to allow removal of tissues (other than blood) from your body for accurate genetic testing. Only you can decide if that is good for you…

Yet another dimension is being added to “personalized medicine”. The biology of our bodies includes features that are manifested and influence locally and systemically (globally). The genetic information is less global than previously thought. Thus the testing, treatment and care will need to be not only tailored to the individual, but also to the specific tissue/body component affected and targeted for prevention or cure of the disease.

So, coming back to the old tried and true wisdom, when it comes to our most precious piece of real estate, our own body, we will need to chose wisely the location (of genetic testing, treatment, etc.)…

Read Full Post »

Personalized medicine is going through the usual cycle: from an “out-there” idea to a buzz word, to current band wagon everyone must get on. If we must, we must… but as it turns out, there are many wagons introduced as “personalized medicine” that are pulling into the station… Which is the real one?

A major obstacle is that personalized medicine means different things to different people. However, that should not be a deal breaker (yet) because nobody can claim to have the whole or the only correct picture of what it should look like. There are many considerations, including scientific, economic, political, and ethical, which had been intelligently discussed in other places. I only want to bring up one issue that seems basic, yet hopefully we all realize it’s a sine-qua non for realizing personalized medicine. This issue has everything to do with the common denominator of all the various visions of personalized medicine: YOU, the individual patient. The individual patient is emerging from being lost somewhere in the average value derived from the many participants in a humongous clinical study, to being the sole focus of attention in the development of an individualized health strategy. Each patient is about to become special (not only to his mother!).  Wow! Now what?!?

In developing a personalized therapy and a whole personalized health strategy for you as an individual, we are now going to need the complete medical picture of you. A big question becomes how could someone get all medical information that has already been collected about each of us? If you are like me, you have moved a few times and thus you’ve changed your primary and other specialist physicians; you had a few different jobs offering different health insurance plans. If you are like me, you might have seen these health care workers/places only once. You might have had specific medical tests done more than once, but chances are that many results were never looked at comparatively. However, an increasing number of experts are agreeing that we are indeed so different from each other, that the real value of various test emerges by comparing longitudinally the values collected at different time points for the same person/patient. The opportunity to harvest this value from my test has been certainly lost in the many shuffles of my paper medical files. I say this because I unsuccessfully tried to extract my own medical information from previous providers. I then checked on their obligation in terms of time for which the records needed to be kept. Did you know this is not officially specified? There goes all the time I have spent repeatedly filling in similar questionnaires, all the time and money spent on all those repeated tests. Unless one has been really obsessive about it, one’s medical picture (get an idea of what this might contain) is a puzzle with pieces scattered or even buried or lost all over the place. In my case, the only thing I’ve received were postcards simply stating that there was nothing special to note about my tests, no numbers for my own personal records. The inherited fragmentation of the health care system in the US is currently a major barrier to personalized medicine. Various types of medical information currently collected throughout one’s life, along with new genetic information (equated by some with personalized medicine) could be added up to create the overall medical picture of oneself. This IS the basis for any rational strategy to personalize prevention or therapy of one’s medical problems. 

Now we come to the other important part of this question: are we willing to let all this information about us be gathered and put to use? Economical and ethical considerations among others put aside, is the current mind set in the US itself undermining the patients’ willingness to let a complete medical picture be put together and “immortalized” in a personal electronic format?  Many personal topics are off limits even among good friends, a preference that applies of course to personal medical information. Since living here I learned that people place great value on “personal space”. People do not want to feel cramped in any way, spatially or physiologically. In addition, the individual’s uniqueness further fades away by the wide application of a great equalizer. When it comes to first names, one of our most personal and defining feature, many Americans prefer generic names. Foreigners are likely to have to accept one themselves, or maybe some short version of their name. I myself was re-baptized by associates “Dr. Z” (or even just “Z”). I had to accept it at some point (I like my first name!), figuring Dr. Z should be unique enough to represent me. Then one day, I was surprised to learn that my personal physician had voluntarily and officially changed his fist name to the initial Z and shortened his last name to the first few letters, exasperated by complains about needing to remember or pronounce his actual name.  Dr. Z here to see Dr. Z!”… It did not end there, a friend signaled that she had heard of another Dr. Z (this one of a “certain” fame). So, apparently I had managed to become one of the generic Drs. Z…

Does anybody still harbor the hope we could achieve personalized health care without comprehensive personal health records?  A lot of people will need to get comfortable soon with the idea of allowing the collection and use of the information that makes them unique from a medical point of view, or else there can be no personalized medicine.

Please comment here (constructively interfere) and/or join our discussion at BIO2009.

See more: articles on personal health records  from Medline Plus A service of the National Library of Medicine and National Institutes of Health (NIH) and FAQs about your health record

Read Full Post »

We all are, have been, or will be at some point in our lives, users/consumers of medical products, that is unless someone is a “Superman/woman”. We all have thoughts and specific opinions about what we would like or expect. Two great examples were provided by answers to my previous request to define medical innovation. Kathy said:” From a consumer perspective, I want to see new products and care that consider the quality of my life and my body – not the statistical average”. Allen Fahden commented more broadly in response to the same:Life science/medical innovation means to me that the model of reaction to failure gets updated with preventing failure.” Kathy is expressing the growing support for “personalized medicine”, Allen is touching upon the need to shift more towards preventive medicine.

My own view as a consumer is that I subscribe 100% to these two goals. I should say I did not know or discuss with either Kathy or Allen before they offered their visions on life science/medical innovation. Let’s see what might be the answer to these opinions from the other perspectives.

Read Full Post »

%d bloggers like this: